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小鼠一次口服吡喹酮200～600 mg/kg后,对感染血吸虫有保护作用。感染后15min至2h,自这些小鼠感染部位的皮肤分离的童虫,部分或大部分已死亡。另一方面,钻穿服药鼠离体皮肤的尾蚴数亦明显减少。进一步分析的结果表明,在水中,血吸虫尾蚴对吡喹酮极其敏感。由于小鼠口服吡喹酮后,药物可自其皮肤排泌,故以水涂擦皮肤时,溶于水中的吡喹酮即对血吸虫尾蚴起作用,并认为这是吡喹酮产生预防作用的主要原因。
Once oral administration of praziquantel 200 ~ 600 mg / kg, the mice have a protective effect against schistosomiasis. From 15 min to 2 h after infection, the sperm, isolated from the skin of the infected area of these mice, have died, in part or in large part. On the other hand, the number of cercariae on the skin of the drinkers also decreased significantly. Further analysis of the results showed that in water, cercariae Schistosoma is extremely sensitive to praziquantel. Since the mouse oral praziquantel, the drug can be excreted from the skin, so water rubbed the skin, dissolved in water praziquantel that cercariae of schistosome play a role, and that this is the preventive effect of praziquantel main reason.