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肠球菌对糖肽类的耐药表型分VanA、VanB和VanC三种.VanA型最常见,耐药质粒携带转座子Tnl546.Tnl546带有一系列耐药基因,它们的基因产物共同作用,导致菌株对糖肽类药物耐药.其中连接酶(VanA)和脱氢酶(VanH)催化合成D-Ala-D-Lac,替代D-Ala-D-Ala连接入肽聚糖前体,阻止了糖肽与细胞壁的结合.D,D-二肽酶(VanX)通过水解D-Ala-D-Ala而抑制正常肽聚糖前体的合成.VanR-VanS二元调节系统在糖肽存在时,作为信号转导系统激活VanH、VanA和VanX共同转录.
The resistant phenotype of enterococci to glycopeptides is divided into VanA, VanB and VanC.3 The most common type of VanA, transfectant resistant plasmid carrying Tnl546.Tnl546 with a series of drug resistance genes, their gene products together, resulting in The strain was resistant to glycopeptide drugs, in which D-Ala-D-Lac was catalyzed by VanA and dehydrogenase (VanH) instead of D-Ala-D-Ala, Glycopeptide binding to cell walls D, D-dipeptidase (VanX) inhibits the synthesis of normal peptidoglycan precursors by hydrolyzing D-Ala-D-Ala. VanR-VanS binary regulatory system, in the presence of glycopeptides, As a signal transduction system activates VanH, VanA co-transcribes with VanX.