论文部分内容阅读
为了验证降低增高的血清胆固醇能减少中年男性缺血性心脏病发病率的假设,1965年在爱丁堡、布达佩斯和布拉格三个欧洲中心合作进行了一次双盲试验,用没有严重副作用的安妥明降低血清胆固醇,观察缺血性心脏病发病率的变化。方法:受试者15,745名男性,受试开始时年龄80～59岁,平均受试5.3年,共积累83,534个受试年。把30,000名志愿者,根据血清胆固醇高低,等分为高、中、低三组。在高胆固醇组中随机抽样一半约5,000人作为治疗组(组I),每日给安妥明1.6克。另一半5,000人作为对照组(组Ⅱ),给予含有橄榄油胶囊的安慰剂。在低胆固醇组中随机抽样5,000
To test the hypothesis that lowering elevated serum cholesterol reduces the incidence of ischemic heart disease in middle-aged men, a double-blind trial was conducted in 1965 at three European centers in Edinburgh, Budapest, and Prague, with a reduction in clofibrate without serious side effects Serum cholesterol, observed changes in the incidence of ischemic heart disease. METHODS: Subjects 15,745 men, aged 80-59 years at the start of the study, averaged 5.3 years, accumulatively 83,534 years of testing. According to the level of serum cholesterol, 30,000 volunteers were equally divided into high, medium and low groups. About half of the patients in the high cholesterol group were randomly selected as the treatment group (Group I) and 1.6 grams of clofibrate daily. The other half, as control group (Group II), were given placebo containing olive oil capsules. A random sample of 5,000 in the low cholesterol group