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目的：研究中国汉族人群中细胞色素P4502E1基因多态性与肺癌的相关性。方法：应用PCR-RFLP方法研究了260例正常对照者和54例肺癌患者细胞色素P4502E1 RsaI基因多态性。结果：对照组A型（c1c1）152例，B型（c1/c2）101例，C型(c2/c2)7例，分别占58.5%, 38.8%和2.7%，c2等位基因频率为0.22；肺癌组A型（c1c1）25例，B型（c1/c2）26例，C型(c2/c2) 3例，分别占46.3%, 48.1%和5.6%, c2等位基因频率为0.30。结论：中国汉族人群中细胞色素P4502E1基因多态性与肺癌无明显相关性。
Objective: To investigate the association between cytochrome P4502E1 gene polymorphism and lung cancer in Chinese Han population. Methods: PCR-RFLP method was used to study the cytochrome P4502E1 RsaI gene polymorphism in 260 normal controls and 54 lung cancer patients. RESULTS: In the control group, there were 152 cases of type A (c1c1), 101 cases of type B (c1/c2), and 7 cases of type C (c2/c2), which accounted for 58.5%, 38.8%, and 2.7%, respectively. The c2 allele frequency was 0.22. In lung cancer group, there were 25 cases of type A (c1c1), 26 cases of type B (c1/c2), and 3 cases of type C (c2/c2), accounting for 46.3%, 48.1% and 5.6%, respectively. The c2 allele frequency was 0.30. CONCLUSION: The polymorphism of cytochrome P4502E1 gene in Chinese Han population is not significantly associated with lung cancer.