论文部分内容阅读
目的:比较分析河南省食管癌高发区同卵双胞胎成员食管、贲门和胃窦黏膜活检组织病理结果,探讨遗传和环境因素对食管和贲门癌变的影响。方法:对108对来自于河南省食管癌高发区的同卵双胞胎进行问卷调查,对其中22对自愿接受胃镜检查者进行黏膜活检组织病理学检查。结果:①108对同卵双胞胎中,共发现癌症13例,其中食管癌7例(均为男性,单发),食管癌发生率0.065%(7/108)。②接受胃镜检查的22对双胞胎中4例食管癌患者,1例胃癌患者,癌前病变3例,均为单发;18对未患癌患者中,3对慢性轻度食管炎和1对慢性浅表性胃炎为双发,其余14对所患疾病均为单发。结论:环境因素对食管癌变的影响远大于遗传因素。
OBJECTIVE: To comparatively analyze the biopsy results of esophageal, cardia and antral mucosa of identical twins in Henan esophageal cancer high incidence area and to explore the influence of genetic and environmental factors on the carcinogenesis of esophagus and gastric cardia. Methods: 108 pairs of identical twins from high risk area of esophageal cancer in Henan Province were surveyed, of which 22 pairs of voluntary endoscopy were mucosal biopsy histopathological examination. Results: ①108 pairs of identical twins, 13 cases were found cancer, including 7 cases of esophageal cancer (both men, single), the incidence of esophageal cancer was 0.065% (7/108). ② Among the 22 pairs of twins undergoing gastroscopy, 4 cases of esophageal cancer patients, 1 case of gastric cancer and 3 cases of precancerous lesions were single; among the 18 cases of non-cancer patients, 3 were chronic mild esophagitis and 1 chronic Superficial gastritis is double hair, the remaining 14 pairs of diseases are single. Conclusion: The influence of environmental factors on esophageal cancer is far greater than genetic factors.