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生物活性多肽的领域近年来有很大扩展,尤其是发现了很多具有激素功能的多肽,也可以作为中枢及周围神经系统的神经递质或者神经调节剂。现已弄清,多肽是使身体各部分形成整体和精确调节机体各种功能的主要物质。生物活性多肽的氨基酸顺序一经确定,不仅为化学家打开了合成天然分子的道路,而且可以合成其他类似物。最近,多肽合成技术的进步已使小分子和中等分子多肽的合成成为常规工作,而且有可能合成大分子肽甚至小分子蛋白质。合成生物活性多肽类似物有几个理由。首先,我们要了解多肽-受体相互作用的本质,因为多肽具有很多能够与受体发生相互
The field of bioactive peptides has greatly expanded in recent years, in particular the discovery of many hormone-functional polypeptides, as well as neurotransmitters or neuromodulators in the central and peripheral nervous system. It has now been clarified that polypeptides are the major substances that make the various parts of the body integral and precisely regulate various functions of the body. Once the amino acid sequence of bioactive peptides has been established, not only has chemists opened the way for the synthesis of natural molecules, but other analogs have also been synthesized. More recently, advances in peptide synthesis have made the synthesis of small and mid-sized polypeptides routinely made and the potential for the synthesis of macromolecular peptides and even small molecule proteins. There are several reasons for the synthesis of bioactive peptide analogues. First, we need to understand the nature of the peptide-receptor interaction because the polypeptide has a lot to do with the receptor