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静脉血小板聚集是心血管疾病的重要致病因素.在动脉血栓形成的病因中血小板起着重要作用,可引起心脑循环障碍,心脑梗塞,以及在心脏和血管手术中也有产生栓塞的危险.血小板聚集机理血小板在聚集前通过许多不同的途径被激活.细胞浆中Ca~(2+)浓度增加是其共同特征.大多病理性血小板激活剂都可通过花生四烯酸(AA)依赖和非依赖机理产生聚集,它们的相对作用取决于激活剂的类型和浓度.AA依赖的过程是由ADP、肾上腺素和低浓度胶原
Platelet aggregation is an important causative agent of cardiovascular disease. Platelets play an important role in the pathogenesis of arterial thrombosis, causing cardiovascular and circulatory disorders, heart and brain infarction, and also the risk of embolism during heart and vascular surgery. Platelet Aggregation Mechanism Platelets are activated by many different pathways before they are aggregated.It is their common feature that increased concentrations of Ca2 + in the cytoplasm.Most of the pathological platelet activators are activated by arachidonic acid (AA) -dependent and non- Dependent mechanism of aggregation, their relative role depends on the type and concentration of activators.AA-dependent process is composed of ADP, epinephrine and low concentrations of collagen