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通常认为,胎脑的发育是由神经营养因子调节的,其中包括神经生长因子、纤维母细胞生长因子、胰岛素样生长因子-Ⅰ、脑衍生的生长因子、神经营养蛋白-3、神经营养蛋白-4/5等。hCG和LH是否具有神经营养作用的问题从未研究过。有研究表明将胎鼠脊索切除后用hCG可使其大大恢复,而植入侧脑室的肾上腺髓质在应用hCG后生长状态况更佳。故有必要研究胎鼠脑组织中是否也与成年鼠和新生鼠一样含功能性LH/hCG受体,以及外源性hCG是否具有神经营养作用。 从胎龄19天的胎鼠脑组织中分离出神经元,在
It is generally believed that fetal brain development is regulated by neurotrophic factors including nerve growth factor, fibroblast growth factor, insulin-like growth factor-I, brain-derived growth factor, neurotrophin-3, neurotrophin- 4/5 and so on. The question of whether hCG and LH have neurotrophic effects has never been studied. Studies have shown that fetal hysterectomy with hCG can greatly restore the spinal cord, while the adventitial medulla of the lateral ventricle after growth in the application of hCG better. Therefore, it is necessary to study whether fetal brain tissue also contains functional LH / hCG receptor as well as exogenous hCG with neurotrophic effects in adult mice and neonatal rats. Neurons were isolated from fetal rat brain tissue at 19 days of gestation