【摘 要】
：
AIM:To investigate the effect of proinflammatory cytokine and anti inflammatation cytokine on liver and lung tissues in rats with endotoxemia.METHODS:Male Wista
【机 构】
：
Reseach Department of Burn Institute,304th Hospital of PLA,Beijing 100037,China
【基金项目】
：
Tenth Five year Plan;
论文部分内容阅读
AIM:To investigate the effect of proinflammatory cytokine and anti inflammatation cytokine on liver and lung tissues in rats with endotoxemia.METHODS:Male Wistar rats were randomly divided into 4 groups: group treated with stimulating vagus nerve, group receiving lipopolysaccharide(LPS) intravenous injection after transecting vagus nerve, group treated with sham operation and group treated with injecting LPS intravenously alone, and then measured the levels of TNF α in liver and lung and those of cortisol and Alanine aminotransferase (ALT) in plasma.RESULTS:Compared with group treated with sham operation,LPS treated groups showed a significant increase in TNF level, which was at most 15 fold higher than that of the former group.There was a significant decrease in TNF level in group treated with stimulating vagus nerve,compared with both group receiving LPS intravenous injection after transecting vagous nerve and group treated only with LPS.In addition,we observed plasma cortisol level in LPS treated group was much higher than other 3 groups and the plasma ALT level was greatly lower than that of group treated only with LPS.CONCLUSION:Stimulating vagous nerve can significantly decrease the production of proinflammatory cytokine and alleviate inflammation in rats with endotoxemia.
其他文献
探讨 2 7例房室结折返性心动过速 (AVNRT)病人射频消融术 (RFCA)中房室结前传有效不应期 (ERP)变化的意义 ,应用心房程序刺激法测定放电前后房室结快慢径前传ERP并据此指导治
有关神经干细胞的研究已成热点.神经干细胞的分化、迁移受内因(基因调控)和外因(细胞周围环境)等因素的影响.体外模型的建立,可以将很多因素进行量化或单一化,并进行生理环境的模拟控制,为神经干细胞生物学特性的研究提供了很好的手段.本文就神经干细胞发育过程中分化、迁移调控机制的研究现状作一综述.
目的研究压力对大鼠颈总动脉血管平滑肌细胞整合素β3、桩蛋白和纽蛋白的分布与表达的影响,探讨它们在血管平滑肌细胞的机械应力信号转导中的作用.方法不同压力(160 mmHg和80
目的 :研究转化生长因子 βI型受体 (TβRⅠ )与胆囊癌细胞增殖的关系 ,并探讨TβRⅠ在胆囊癌变过程中的作用机理。方法 :应用S P免疫组织化学技术对 35例原发性胆囊癌 ,1 0
目的 应用微阵列基因芯片比较三氧化二砷（As2O3）对HL60细胞作用后细胞周期素相关基因表达谱的变化。方法 As2O3作用于HL60细胞，TRIzol试剂一步法提取作用前后HL60细胞的mRNA，经逆转录反应，用Cy3标记的脱氧三磷酸尿苷（Cy3-dUTP）和Cy5-dUTP两种不同的荧光染料将处理前后的HL60细胞mRNA分别标记成两种DNA探针，并与载有一组靶基因的表达谱芯片进行杂交，通过扫
观察血管内皮生长因子在胃癌组织中的表达与胃癌细胞分化、侵袭和转移之间的关系,探讨其在胃癌 发生发展及转归过程中的作用机制,为胃癌转移的抗血管治疗提供科学依据。
To
目的:了解椎体成形术中注入椎体内骨水泥表面的温度变化情况.方法:对5例(6个椎体)骨质疏松性椎体压缩骨折患者行经皮穿刺椎体成形术(PVP),在治疗过程中用计算机控制热电偶型
目的:探讨急性心肌梗塞(AMI)直接经皮腔内冠状动脉成形术(PTCA)的适应证、时机、可行性与安全性.方法:对76例急性Q波型心肌梗塞患者行直接PTCA治疗并随访.结果:76例患者共有7
AIM:To provide a new way of operation for repairing fracture necrosis of proximal humerrus. METHODS:Observing the course,branches and distributions of thoracoac
AIM:To investigate the effect of allogeneic acellular dermal matrix(ADM) on cograft in joint functional positions of patients with post burn plastic operation.