静脉注射双室模型药物动力学参数的简便求法

• 作 者: 陈幼亭 林承仪
• 机 构: 苏州医学院附属第一医院药剂科,江苏常熟市第一人民医院药剂科,
• 出 处: 现代应用药学
• 发表日期: 1988年01期
• 关键词: 药物动力学参数 双室 头孢孟多 苯妥英钠 剩余法 血药浓度 血液样品 非线性拟合 数法 给药剂量

对于具有双室模型特点的药物,例如庆大霉素、硫酸镁、苯妥英钠、头孢孟多等,为了求得其动力学参数,一般常采用残数法(剩余法)或非线性拟合法。这两种方法常常要求采集七到八次甚至更多次血液样品,计算过程复杂。非线性拟合法则非依赖计算机不可。本文介绍一种静脉注射双室模型药物动力学参数的简便求法,只采集四次血液样品,计算简便,可迅速获得药物动力学参数。

For drugs with the characteristics of a two-compartment model, such as gentamicin, magnesium sulfate, phenytoin, cefmeta, etc., in order to obtain the kinetic parameters, often using the residual method (residual method) or non-linear fitting method. Both of these methods often require taking seven to eight or more blood samples and the calculation is complex. Non-linear fitting rules are not dependent on the computer. This article describes a simple method of intravenous injection of pharmacokinetic parameters of the double chamber model, collecting only four blood samples, the calculation is simple, rapid access to pharmacokinetic parameters.