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克拉维酸和羟氨苄青霉素联用已成功地治疗了由产生β-内酰胺酶菌类引起的感染,也已对克拉维酸与替卡西林的联用开展了研究.克拉维酸与替卡西林联用使抗生素的实用性得到增加,并有希望成为有效的肠胃外广谱制剂.克拉维酸和β-内酰胺剂联合的抗菌效果取决于微生物和它们产生的β-内酰胺酶、克拉维酸和β-内酰胺剂的用量、以及其它因素诸如药物与菌类接触时间和青霉素靶位.
Clavulanic acid and amoxicillin have been successfully used in the treatment of infections caused by the beta-lactamase-producing bacteria, and clavulanic acid and ticarcillin have also been studied. The combination of Xilin to increase the availability of antibiotics and hopeful to be an effective parenteral broad-spectrum preparation.The combination of clavulanic acid and β-lactam antibacterial effect depends on the microorganisms and their production of β-lactamase, carat Retinoids and beta-lactam agents, as well as other factors such as drug-to-fungal contact time and penicillin target sites.