关于糖精的争议

• 作 者: 叶芜
• 出 处: 国外医学参考资料(卫生学分册)
• 发表日期: 1978年01期
• 关键词: 人工甜味剂 膀胱肿瘤 大鼠 膀胱癌 出生后 子宫 剂量 体重 子代 雌雄

1977年3月9日美国食品和药物管理局(FDA)建议禁止销售美国市场上仅有的人工甜味剂——糖精(saccharin)。这个决定主要根据加拿大的大鼠实验,该实验用糖精喂饲100只大鼠(雌雄各半),剂量为饲料的5%(约2,500mg/kg体重,相当干一个人每天饮800瓶12盎司瓶装汽水),有3只发生膀胱癌,而其子代(在子宫内即接触糖精,出生后又喂饲糖精),14%发生膀胱肿瘤(见下表)。

March 9, 1977 The U.S. Food and Drug Administration (FDA) advised against the sale of saccharin, the only artificial sweetener in the United States. The decision was based primarily on a Canadian rat experiment, which fed 100 rats (half male and female) with saccharin at 5% of the diet (about 2,500 mg / kg of body weight, which is equivalent to drinking 800 12-oz Bottled soft drinks), 3 had bladder cancer, and their offspring (in the womb that contact saccharin, after birth, fed saccharin), 14% of bladder tumors (see table below).