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纤维结合蛋白,又称纤维结合素(fibro-nectin,Fn)是一种高分子糖蛋白,存在于血浆及细胞表面,是细胞与细胞外纤维、基质间的一种联结介质。最早由 morrison 氏1948年在血浆中发现。随着对纤维结合素分子结构、生物学特性.生理功能、体内分布及病理变化等方面认识的深入,初步发现 Fn 和细胞、纤维、基质间的接触、细胞的分化和间变、巨噬细胞的吞噬功能、创伤愈合、组织炎症、纤维化及硬化过程都有非常密切的
Fibrin-binding protein, also known as fibronectin (Fn) is a kind of high molecular weight glycoprotein, which exists in plasma and cell surface. It is a binding medium between cells and extracellular fibers and matrix. Morrison was first discovered in plasma in 1948. With the further understanding of the molecular structure, biological characteristics, physiological functions, distribution in vivo and pathological changes of fibronectin, it was initially found that the contact of Fn with cells, fibers, matrix, cell differentiation and metaplasia, macrophages Phagocytosis, wound healing, tissue inflammation, fibrosis and hardening process has a very close