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Landau Kleffner综合征是年龄依赖性癫疒间 综合征 ,常发生于儿童期 ,病因不清 ,可能与免疫、脑神经元损伤、遗传因素有关。其临床特点为获得性失语、癫疒间 发作和脑电图颞区异常放电 ,失语多为言语听觉失认 ,患儿听力正常 ,但失去言语理解能力 ,表现为缄默 ,失语可持续 2周至数年 ,部分患儿终生语言障碍。大部分患儿有癫疒间 发作 ,常于 15岁前缓解 ,抗癫疒间 药可控制癫疒间 发作 ,但对于失语无明显治疗效果 ,肾上腺皮质激素可明显改善语言功能
Landau Kleffner syndrome is age-dependent epilepsy syndrome, often occurs in childhood, the etiology, may be related to immunity, neuronal damage, genetic factors. The clinical features of acquired aphasia, epileptic seizures and EEG temporal abnormal discharge, aphasia mostly speech and hearing loss, children with normal hearing, but lost the ability to understand speech, the performance of silence, aphasia can continue for 2 weeks to the number Years, some children with life-long language disorders. Most children have epileptic seizures, often before the age of 15 to relieve, anti-epileptic drugs can control epileptic seizures, but no significant effect on treatment of aphasia, adrenal cortex hormones can significantly improve the language function