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目的:研究双肺大容量灌洗治疗对煤工尘肺患者肺功能及6分钟步行试验的影响。方法:入选29例已明确诊断为煤工尘肺的患者,行双肺大容量灌洗,并于灌洗前、灌洗后2周分别询问其症状,行6分钟步行试验及肺功能检查。结果:29例煤工尘肺患者在行双肺大容量灌洗后,与灌洗前相比胸闷、呼吸困难明显改善(P<0.05),但是咳嗽、咳痰等症状的改善无统计学意义(P>0.05)。患者在行双肺大容量灌洗前肺功能表现为小气道功能受损或阻塞性通气功能障碍者有17人。和灌洗前相比,这组患者最大通气量(MVV)和6分钟步行试验明显改善,分别为(96.8±14.1)%vs(91.2±15.2)%,(448.8±60.7)mvs(422.6±46.2)m,而肺总量(TLC)较灌洗前降低(119.4±15.0%vs115.8±14.7%,P<0.05)。结论:双肺大容量灌洗治疗在短时间内可以改善症状,提高患者的肺功能及运动耐量,提高患者的生活质量。
OBJECTIVE: To study the effect of double lung volume lavage treatment on lung function and 6-minute walk test in coal workers with pneumoconiosis. Methods: Twenty-nine patients with pneumoconiosis diagnosed as coal worker’s pneumoconiosis were enrolled in this study. Lungs of large capacity were lavaged before lavage and 2 weeks after lavage. Their symptoms were examined and their 6-minute walking test and pulmonary function tests were performed. RESULTS: Twenty-nine patients with pneumoconiosis had a significant improvement in chest tightness and dyspnea (P <0.05), but no significant improvement in symptoms such as cough and sputum (P> 0.05) P> 0.05). Patients undergoing lung perfusion in both lungs before lung perfusion showed small airway function impaired or obstructive ventilatory dysfunction were 17 people. The MVV and 6-minute walking tests in this group were significantly improved compared with those before lavage (96.8 ± 14.1)% vs (91.2 ± 15.2)%, (448.8 ± 60.7) mvs (422.6 ± 46.2) ) m, while the total lung volume (TLC) was lower than that before lavage (119.4 ± 15.0% vs115.8 ± 14.7%, P <0.05). Conclusions: Lungs with large capacity lavage can ameliorate the symptoms in a short time, improve lung function and exercise tolerance, and improve the quality of life of patients.