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目的了解儿童大骨节病症状体征在临床诊断和X线诊断病例中的分布特点,进行对比分析,为全面诊断儿童大骨节病提供一定的理论依据。方法采取整群随机抽样的方法抽取大骨节病病区2006名6～13岁儿童进行研究。结果两类诊断病例数存在统计学差异(χ2=67.052,P=0.001),两类诊断患病率结果在性别间无显著性差异(χ2=0.147,P=0.702;χ2=1.501,P=0.220),但患病率均有随年龄增加的趋势。单因素和多因素分析显示症状体征在两类诊断病例中分布不同。结论儿童大骨节病症状体征在临床诊断与X线诊断病例中的分布存在差异,临床应用时应两类诊断指标综合考虑。
Objective To understand the distribution characteristics of symptoms and signs of Kashin-Beck disease in clinical diagnosis and X-ray diagnosis, and to provide a theoretical basis for the comprehensive diagnosis of Kashin-Beck disease in children. Methods A randomized cluster sampling method was used to select 2006 children aged 6 to 13 years old from Kashin-Beck disease area. Results There was a statistically significant difference between the two types of diagnostic cases (χ2 = 67.052, P = 0.001). There was no significant difference between the two groups in the prevalence of the two diagnoses (χ2 = 0.147, P = 0.702; ), But the prevalence trends with age. Univariate and multivariate analyzes showed that the signs and symptoms differed between the two types of diagnostic cases. Conclusion There are differences in the distribution of symptoms and signs of Kashin-Beck disease in clinical diagnosis and X-ray diagnosis. Two clinical indexes should be considered in clinical application.