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目的通过对2008～2012年军事医学科学院附属医院抗菌药物使用情况的调查分析,评价该院近5年抗菌药物的应用状况和用药合理性。方法利用计算机管理软件检索2008～2012年军事医学科学院附属医院抗菌药物的品种、剂型、使用量和用药金额,并进行分类、排序和汇总;应用限定日剂量(DDD)法统计并计算抗菌药物的用药频度(DDDs)、日均费用(DDDc)和用药金额与DDDs的排序比,分析临床用药情况。结果军事医学科学院附属医院抗菌药物使用以注射剂型为主,年销售额占总用药金额比例最高达18.57%,抗真菌药使用金额最高,头孢菌素类药使用率最高;2011年该院抗菌药物使用呈明显调整,次年用药金额显著降低,其占总金额比例降至13.70%,用药频度显著下降,药品用量和结构均有较大变化。结论军事医学科学院附属医院抗菌药物使用基本合理,干预效果显著,但仍存在问题,须持续规范其使用,以确保临床用药更加安全、有效。
Objective To investigate the use of antimicrobial agents in the Affiliated Hospital of the Academy of Military Medical Sciences from 2008 to 2012 and evaluate the application and rational use of antimicrobial agents in the past five years. Methods The computer software was used to search the varieties, dosage forms, dosage and dosage of antibacterials in the Affiliated Hospital of Academy of Military Medical Sciences from 2008 to 2012 and to classify, sort and summarize the antimicrobial agents. The DDD method was used to calculate and calculate the antibacterials DDDs, DDDc, and DDDs were used to analyze the clinical use of drugs. Results The use of antimicrobial agents in the Affiliated Hospital of Academy of Military Medical Sciences was mainly in the form of injection. The annual sales volume accounted for 18.57% of the total amount of drug use, the highest amount of antifungal drug used and the highest utilization rate of cephalosporins. In 2011, The use of medication was significantly adjusted, the amount of the following year medication significantly reduced, the proportion of the total amount fell to 13.70%, the frequency of medication decreased significantly, the amount and structure of the drug have a greater change. Conclusion The use of antibacterials in the Affiliated Hospital of Academy of Military Medical Sciences is basically reasonable and the effect of intervention is remarkable. However, there are still some problems. The use of antibacterials should be continued to ensure the clinical use of drugs is safer and more effective.