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目的研究分析部分重要凝血和抗凝因子与脑梗死发生的关系。方法采用凝固法测定急性脑梗死组、非脑血管疾病对照组和正常健康对照组血浆中纤维蛋白原含量、凝血因子Ⅶ和Ⅷ活性、蛋白 C 活性,以及凝血酶原时间和活化部分凝血活酶时间等指标,并在三组间进行比较。结果急性脑梗死组纤维蛋白原含量和凝血因子Ⅶ活性显著高于非脑血管组和正常对照组.脑梗死组凝血因子Ⅷ活性高于其他两组,但与正常组比较差异不显著;脑梗死组的蛋白 C 活性显著低于其他两组;上述所有指标在非脑血管疾病组和正常对照组之间无显著差异;凝血酶原时间和活化部分凝血活酶时间在三组间无显著差异。结论纤维蛋白原浓度升高、凝血因子Ⅶ和Ⅷ活性升高以及蛋白 C 活性下降与脑梗死的发生存在一定关联性,提示纤维蛋白原等因素可能是脑梗死发生和发展中的重要危险因素。
Objective To study the relationship between some important coagulation and anticoagulation factors and the occurrence of cerebral infarction. Methods The plasma fibrinogen levels, coagulation factors Ⅶ and Ⅷ activities and protein C activity in acute cerebral infarction group, non-cerebrovascular disease control group and normal healthy control group were determined by coagulation method. Prothrombin time and activated partial thromboplastin Time and other indicators, and in the three groups to compare. Results The levels of fibrinogen and factor Ⅶ in acute cerebral infarction group were significantly higher than those in non-cerebral vascular group and normal control group.The activity of factor Ⅷ in cerebral infarction group was higher than that in other two groups, but the difference was not significant compared with normal group Group C protein activity was significantly lower than the other two groups; all of the above indicators in non-cerebrovascular disease group and the normal control group no significant difference; prothrombin time and activated partial thromboplastin time in the three groups no significant difference. Conclusion The increase of fibrinogen concentration, the increase of activity of coagulation factors Ⅶ and Ⅷ, and the decrease of protein C activity have some correlation with the occurrence of cerebral infarction. These results suggest that fibrinogen and other factors may be important risk factors in the occurrence and development of cerebral infarction.