【摘 要】
：
准轮烷/轮烷是超分子化学领域内的一类重要成员,其结构可在外界刺激下发生改变,这一特点使其在分子机器制备方面取得了广泛的应用。近年来,由于其结构的特殊性,在药物载体领
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准轮烷/轮烷是超分子化学领域内的一类重要成员,其结构可在外界刺激下发生改变,这一特点使其在分子机器制备方面取得了广泛的应用。近年来,由于其结构的特殊性,在药物载体领域也开始引起人们的关注。本文对近十年来准轮烷/轮烷在药物载体领域内的发展情况进行了综述,重点概述准轮烷修饰的硅纳米粒子和主体-轮烷这两类药物载体的发展历程以及各自的优缺点,最后展望了准轮烷/轮烷在药物载体领域的发展方向。
Quasi-rotaxane / rotaxane is a kind of important member in the field of supramolecular chemistry. Its structure can be changed under external stimuli. This feature has made it widely used in molecular machinery preparation. In recent years, due to its structural specificity, it has also drawn people’s attention in the field of drug carriers. This review summarizes the recent developments in the field of drug carriers in quasi -rotaxanes / rotaxins in the past decade. The development of these two types of drug carriers, such as chitosan modified silicon nanoparticles and host-rotanil, Shortcomings, and finally prospects of the quasi-rotaxane / rotaxane in the field of drug carrier development.
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