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本文研究的目的是检测健康老年人的促甲状腺素(TSH)和甲状腺素(T_4)水平与识别功能之间的关系。对象与方法受试者为75～96岁无痴呆的老年人376例。除外严重抑郁症、精神病和妄想狂18例,以及无精神病诊断但服用精神抑制剂和/或抗抑郁药17例。在同一天晨起采集血标本检测TSH和游离T_4。采用免疫放射量测定分析方法测定TSH,采用放射免疫分析方法测定游离T_4。所有受试者有充分的视觉和听觉能力。
The purpose of this study was to examine the relationship between thyroid-stimulating hormone (TSH) and thyroxine (T_4) levels and cognitive function in healthy elderly. Subjects and Methods The subjects were 376 elderly patients aged 75-96 years without dementia. Excluding severe depression, psychosis and paranoidness, 18 were diagnosed without psychosis and 17 with antipsychotic and / or antidepressant medications. Blood samples were taken on the same morning to detect TSH and free T_4. TSH was determined by immunoradiometric assay and free T_4 was determined by radioimmunoassay. All subjects had adequate visual and hearing ability.