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目的 总结初发急性白血病的疗效及影响因素。方法 对上海地区 2 5 18例初发急性白血病进行回顾性临床总结和分析。结果和结论 急性白血病总完全缓解 (CR)率为 6 0 .4% ,急性髓系白血病 (AML)的CR率为 5 1% ,急性淋巴细胞白血病 (ALL)为 76 .7%。儿童ALL的CR率最高 ,达87 1% ,老年人AML的CR率最低 ,仅为 2 6 %。 1984～ 1994年除M3 的CR率有明显提高外 ,AML和ALL的CR率均无明显提高。诱导缓解方案对CR率有一定影响 ,维甲酸对M3 的疗效再次得到肯定。对ALL患者采用VDLP和VDP方案治疗的疗效优于VP方案。DA和HA方案治疗AML的CR率差异无显著性。
Objective To summarize the curative effect and influential factors of acute leukemia. Methods A retrospective clinical summary and analysis of 2518 cases of acute leukemia in Shanghai area were made. RESULTS AND CONCLUSION: The complete remission (CR) rate of acute leukemia was 60.4%, that of acute myeloid leukemia (AML) was 51%, and that of acute lymphoblastic leukemia (ALL) was 76.7%. The highest CR rate was 87.1% in children with ALL, and the lowest CR rate in elderly AML was only 26%. Between 1984 and 1994, the CR rate of AML and ALL were not significantly increased except for the marked increase of CR rate. The induction of remission has a certain impact on the CR rate, and the efficacy of retinoic acid on M3 is again confirmed. The treatment of ALL patients with VDLP and VDP regimens is superior to the VP regimen. There was no significant difference in CR rate between DA and HA regimen in the treatment of AML.