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目的：研究胆管癌组织中 Ｂｃｌ－２蛋白和 Ｆａｓ－Ｌ蛋白的表达及意义。方法：免疫组化 ＳＰ法。结果；５６例胆管癌中 Ｂｃｌ－２蛋白阳性 ３８例（６７． ８６％）和 Ｆａｓ－Ｌ蛋白阳性 ３１例（５５．３６％），与８例正常胆管中二者的阳性表达２例（２５．００％）、７例（８７．５０％）有显著差异；Ｂｃｌ－２蛋白和Ｆａｓ－Ｌ蛋白在高分化癌（５２．６３％、７３．６８％）、中分化癌（６６．６７％、５７．７１％）、低分化癌（８７． ５０％、３７． ２５％）中的表达相关（Ｐ＜０． ０５）。结论：Ｂｃｌ－２蛋白和 Ｆａｓ－Ｌ蛋白在胆管癌的发生发展中起重要作用，测定Ｂｃｌ－２蛋白和Ｆａｓ－Ｌ蛋白有助于判断胆管癌的恶性程度和预后。
Objective: To study the expression and significance of Bcl-2 protein and Fas-L protein in cholangiocarcinoma. Methods: Immunohistochemical SP method. Results: Of the 56 cases with cholangiocarcinoma, 38 (67.86%) were positive for Bcl-2 protein and 31 (55.36%) were Fas-L protein positive, and 2 cases were positive for 8 cases of normal bile duct (25 cases). (00%), 7 cases (87.50%) were significantly different; Bcl-2 protein and Fas-L protein in well-differentiated carcinoma (52.63%, 73.68%), moderately differentiated carcinoma (66.67% The expression was correlated with 57.71%) and poorly differentiated cancers (87. 50%, 37. 25%) (P<0.05). Conclusion: Bcl-2 protein and Fas-L protein play an important role in the occurrence and development of cholangiocarcinoma. The determination of Bcl-2 protein and Fas-L protein can help to determine the malignant degree and prognosis of cholangiocarcinoma.