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最初认为 IgA 肾病的过程是良性,但最近已观察到 IgA 肾病部分患者可产生肾病综合征、高血压和偶可发展为肾功能衰竭终末期。IgA 肾病在日本、法国、澳大利亚和英国是肾脏疾病中最常见的类型,但在美国却不很普遍。这些事实提示影响机体免疫反应的某种遗传或地理因素可能与 IgA 肾病的发生和发展有关。本文对 IgA 肾病患者的 HLA-A、HLA-B 和 HLA-DR 抗原进行了调查和分析。1972～1980年作者对518例原发性肾小球疾病患者进行了肾活检,证实 IgA 肾病者223例,占43%。作者对其中103例 IgA 肾病患者作了 HLA-A 和HLA-B 抗原的鉴定,对80例 IgA 肾病患者还作了
IgA nephropathy was initially thought to be benign, but it has recently been observed that some patients with IgA nephropathy may develop nephrotic syndrome, hypertension and even developmental end-stage renal failure. IgA nephropathy is the most common type of kidney disease in Japan, France, Australia and the United Kingdom, but not common in the United States. These facts suggest that some genetic or geographical factors that affect the body’s immune response may be related to the occurrence and development of IgA nephropathy. This article investigates and analyzes HLA-A, HLA-B, and HLA-DR antigens in patients with IgA nephropathy. From 1972 to 1980, the authors performed a kidney biopsy of 518 patients with primary glomerular disease and confirmed 223 IgA nephropathy cases (43%). The authors identified HLA-A and HLA-B antigens in 103 patients with IgA nephropathy and also performed 80 patients with IgA nephropathy