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目的对比洛汀新与缬沙坦对老年急性心肌梗死心室重塑的影响。方法选择郑州市第七人民医院的老年急性心肌梗死患者96例作为研究对象,随机分成两组,各48例。对照组:接受急性心肌梗死的常规治疗,并口服缬沙坦。观察组:接受急性心肌梗死的常规治疗,并口服洛汀新。比较治疗前后两组患者NYHA评分、症状评分的变化,观察治疗前后两组患者心功能指标的变化,同时观察治疗前后两者患者心室重塑指标的变化。结果治疗16周后,观察组患者的症状评分低于对照组患者的症状评分,差异具有统计学意义(P<0.05);治疗16周后,观察组患者心功能指标LVEF水平高于对照组患者,而LVESV水平低于对照组患者的LVESV,差异具有统计学意义(P<0.05);治疗16周后,观察组患者心室重塑指标LVMI水平高于对照组患者的LVMI,而LVPWT、IVST水平低于对照组患者的LVPWT、IVST,差异具有统计学意义(P<0.05)。结论洛汀新与缬沙坦在老年急性心肌梗死的治疗中均具有较高的应用价值,能够改善患者的心功能,抑制左室重塑、提升左室收缩的同步性;但临床实践治疗显示洛汀新的临床效果更好。
Objective To compare the effects of losartin and valsartan on ventricular remodeling in elderly patients with acute myocardial infarction. Methods Ninety-six elderly patients with acute myocardial infarction in the Seventh People’s Hospital of Zhengzhou City were selected as study subjects and were randomly divided into two groups of 48 patients. Control group: received routine treatment of acute myocardial infarction, and oral valsartan. Observation group: received routine treatment of acute myocardial infarction and oral Lotensin. The changes of NYHA score and symptom scores before and after treatment were compared. The changes of cardiac function before and after treatment were observed. The changes of ventricular remodeling index in both groups before and after treatment were also observed. Results After 16 weeks of treatment, symptom score of observation group was lower than that of control group, the difference was statistically significant (P <0.05); After 16 weeks of treatment, LVEF level of cardiac function index of observation group was higher than that of control group , While the LVESV level was lower than that of the control group (P <0.05). After 16 weeks of treatment, the level of LVMI in the observation group was higher than that in the control group, while LVPWT and IVST levels The LVPWT and IVST were lower than those in the control group (P <0.05). Conclusion Lotensin and valsartan in the treatment of elderly patients with acute myocardial infarction have a high value, can improve the patient’s cardiac function, inhibition of left ventricular remodeling, increased systolic left ventricular systolic; However, clinical practice showed that Lotensin new clinical effect is better.