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目的观察食管癌组织ＩＬ－２Ｒ的表达和患者血清ＳＩＬ－２Ｒ的变化，探讨ＩＬ－２Ｒ和ＳＩＬ－２Ｒ与食管癌发生、发展的关系。方法采用双抗体夹心ＥＬＩＳＡ法对４２例食管癌患者血清可溶性白细胞介素２受体（ＳＩＬ－２Ｒ）水平进行测定，同时应用即用型ＳＡＢＣ免疫组织化学方法观察ＩＬ－２Ｒ在食管癌组织的表达情况。结果食管癌患者血清ＳＩＬ－２Ｒ水平显著高于正常对照组（Ｐ＜０．０５），并与临床分期有关；ＩＬ－２Ｒ在食管癌组织中阳性表达率５２．４％（２２／４２），显著高于正常食管粘膜组（Ｐ＜０．０５），并与临床分期有关。结论ＩＬ－２Ｒ表达和血清ＳＩＬ－２Ｒ水平可作为临床诊断和判断患者预后的重要参考指标。
Objective To observe the expression of IL-2R in esophageal cancer tissue and the changes of serum SIL-2R in patients, and to explore the relationship between IL-2R and SIL-2R and the occurrence and development of esophageal cancer. Methods Serum soluble interleukin 2 receptor (SIL-2R) levels in 42 patients with esophageal cancer were measured by double-antibody sandwich ELISA. The expression of IL-2R in esophageal cancer tissues was observed by immunohistochemical SABC immunohistochemistry. Happening. Results Serum SIL-2R levels in esophageal cancer patients were significantly higher than those in normal controls (P<0.05), and were correlated with clinical stages. The positive rate of IL-2R in esophageal cancer tissues was 52.4% (22/42). Significantly higher than the normal esophageal mucosa group (P < 0.05), and related to clinical staging. Conclusion The expression of IL-2R and serum SIL-2R can be used as an important reference for clinical diagnosis and prognosis.