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近年发现,大鼠的垂体、下丘脑、嗅球和丘脑中高浓度地合成前列腺素D_2(PGD_2).基于PGD_2刺激大鼠脑片的腺苷酸环化酶的活性,提示在中枢神经系统中,PGD_2可能起着神经调制物的作用.已知PGE_2刺激LH的分泌,本实验研究了PGD_2对清醒阉割大鼠LH分泌的影响.使用体重200～250g的雄性大鼠,阉割四周后,经颈静脉向右心房插管,以备取血样.向侧脑室埋植不锈钢痿管,以备注入药物.分别向侧脑室内注入5μg(5μl)PGD_2,PGE_2或PGD_2的一种代谢
In recent years, it has been found that PGD_2 is synthesized in high concentrations in the pituitary, hypothalamus, olfactory bulb and thalamus in rats.Gradient PGD_2 stimulates the activity of adenylate cyclase in rat brain slices, suggesting that in the central nervous system, PGD_2 May play a role in neuromodulators.It is known PGE2 stimulates the secretion of LH, the experimental study of PGD_2 awake castrated LH secretion in rats.Using weight male rats 250 ~ 250g, castration four weeks after the jugular vein to Right atrium intubation, to prepare for blood samples.Can be implanted into the lateral ventricle of stainless steel fistula, for injection into the drug.Each intracerebroventricular injection of 5μg (5μl) of a PGD_2, PGE_2 or PGD_2 metabolism