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Objective To study the effects of electromagnetic pulse(EMP) on bone metabolism of mice in vivo.Methods Twenty-four male BALB/c mice were divided into a control group and 2 experimental groups(n=8) .The whole-body of mice in experimental groups were exposed to 50 kV/m and 400kV/m EMP,400 pulses daily for 7 consecutive days at 2 seconds intervals.Alkaline phosphotase(ALP) activity,serum calcium concentration and osteocalcin level and trabecular bone volume(BV/TV,%) were measured immediately after EMP exposure by biochemical,ELISA and morphological methods.Results The ALP activity,serum calcium concentration and osteocalcin level and BV/TV in experimental groups remained unchanged after EMP exposure.Conclusion Under our experimental conditions,EMP exposure cannot affect bone metabolism of mice in vivo.
Objective To study the effects of electromagnetic pulse (EMP) on bone metabolism of mice in vivo. Methods Twenty-four male BALB / c mice were divided into a control group and 2 experimental groups (n = 8). The whole-body of mice in experimental groups were exposed to 50 kV / m and 400 kV / m EMP, 400 pulses daily for 7 consecutive days at 2 seconds intervals. Alkaline phosphotase (ALP) activity, serum calcium concentration and osteocalcin level and trabecular bone volume (BV / TV, %) were measured immediately after EMP exposure by biochemical, ELISA and morphological methods. Results The ALP activity, serum calcium concentration and osteocalcin level and BV / TV in experimental groups remained unchanged after EMP exposure. Confluence Under our experimental conditions, EMP exposure can not affect bone metabolism of mice in vivo.