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Survivin是新近发现的凋亡抑制蛋白(IAP)家族中新的一员,其抗凋亡作用的机制可通过Caspase途径和非Caspase途径实现,属于一种结构独特的哺乳类凋亡抑制蛋白(IAPs)家族成员,Survivin同时具有肿瘤组织特异性高表达的特性,研究已证实多种常见肿瘤如胃癌、大肠癌、
Survivin is a newly discovered member of the apoptosis-inhibiting protein (IAP) family. Its anti-apoptotic mechanism is mediated by Caspase pathway and non-caspase pathway. Survivin belongs to a unique mammalian apoptosis inhibitory protein (IAPs) ) Family members, Survivin also has the characteristics of tumor tissue-specific high expression, the study has confirmed a variety of common tumors such as gastric cancer, colorectal cancer,