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目的探讨老年癫痫患者卡马西平、丙戊酸血药浓度监测情况。方法对262例常规服用卡马西平、丙戊酸钠老年癫痫患者进行血药浓度监测。结果卡马西平组有13.75%低于有效血药浓度,5%高于有效血药浓度,81.25%达到有效血药浓度。而丙戊酸组有51.96%低于有效血药浓度,3.92%高于有效血药浓度,44.12%达到有效血药浓度。丙戊酸组达到有效血药浓度的比率明显低于卡马西平组(P<0.01),而两组高于有效血药浓度的比率基本相似(P>0.05)。结论患者在给予卡马西平或丙戊酸钠初次使用剂量后达到有效浓度的比率存在一定差异。临床医师在应用抗癫痫药物时应实施个体化给药。
Objective To investigate the monitoring of plasma concentrations of carbamazepine and valproic acid in elderly patients with epilepsy. Methods 262 patients were routinely taken carbamazepine, sodium valproate elderly patients with epilepsy for plasma concentration monitoring. Results The carbamazepine group had 13.75% lower than the effective plasma concentration, 5% higher than the effective plasma concentration, and 81.25% reached the effective plasma concentration. The valproic acid group 51.96% lower than the effective plasma concentration, 3.92% higher than the effective plasma concentration, 44.12% to achieve effective plasma concentration. Valproic acid group reached the effective plasma concentration ratio was significantly lower than the carbamazepine group (P <0.01), while the two groups were higher than the effective plasma concentration ratio was similar (P> 0.05). Conclusion There is a certain difference in the rate of effective concentration of carbamazepine or sodium valproate after initial administration. Clinicians should administer individualized antiepileptic drugs.