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目的研究无症状脑梗死患者干预性治疗与缺血性脑卒中发生的相关性。方法采用随机、对照的原则,将符合无症状脑梗死诊断标准的89例患者分为2组,对照组45例,只进行控制血糖、血压、血脂等危险因素的治疗;干预组44例,在控制危险因素的基础上进行干预治疗,包括阿司匹林抗血小板治疗、尼莫通保护脑细胞及中药治疗。治疗6个月后测定2组血液流变学指标。结果治疗后干预组各项指标均显著改善(P<0.05或P<0.01),对照组仅低切全血黏度降低(P<0.05)。干预组各项指标均明显低于对照组(P<0.05)。在3年随访期间,对照组发生症状性缺血性脑卒中21例(52.5%)高于干预组12例(29.3%),差异有统计学意义(P<0.05)。结论对无症状脑梗死患者进行干预性治疗,可望降低急性缺血性脑卒中的发生率。
Objective To study the relationship between intervention treatment and ischemic stroke in patients with asymptomatic cerebral infarction. Methods According to the randomized and controlled principle, 89 patients who meet the diagnostic criteria of asymptomatic cerebral infarction were divided into two groups and 45 in control group. Only the control of blood sugar, blood pressure, Control of risk factors based on interventions, including aspirin antiplatelet therapy, nimotop protect brain cells and Chinese medicine treatment. After 6 months of treatment, 2 sets of hemorheology indexes were determined. Results After treatment, the indexes of intervention group were significantly improved (P <0.05 or P <0.01), while the control group only reduced the low cut whole blood viscosity (P <0.05). The intervention group indicators were significantly lower than the control group (P <0.05). During the three-year follow-up period, 21 (52.5%) patients with symptomatic ischemic stroke developed in the control group were significantly higher than those in the intervention group (29.3%), the difference was statistically significant (P <0.05). Conclusion Asymptomatic cerebral infarction in patients with intervention therapy, is expected to reduce the incidence of acute ischemic stroke.