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目的观察以失碳长春碱（Ｎａｖｅｂｉｎｅ）为主的联合化疗治疗晚期乳癌的近期疗效和毒性。方法用失碳长春碱联合阿霉素或５－氟脲嘧啶或顺铂治疗晚期乳癌２０例。结果可评价疗效的１８例中，部分缓解８例，轻微缓解３例，稳定５例，进展２例，无完全缓解病例，有效率４４．４％。化疗后卡氏评分总体评价较化疗前提高（Ｐ＜０．０１），有显著性差异。毒性反应主要是骨髓抑制、消化道反应、脱发、静脉炎，神经毒性亦可见到，多为轻度，无麻痹性肠梗阻发生。结论含失碳长春碱的联合化疗治疗晚期乳癌有较好疗效，但骨髓毒性亦较重，使用时应谨慎
Objective To observe the short-term efficacy and toxicity of decompensated Navebine-based combination chemotherapy for advanced breast cancer. Methods 20 patients with advanced breast cancer were treated with carbogen vinblastine combined with doxorubicin or 5-fluorouracil or cisplatin. Results Of the 18 cases that could be evaluated for efficacy, 8 cases were partially relieved, 3 cases were slightly relieved, 5 cases were stable, 2 cases progressed, and none had complete remission. The effective rate was 44.4%. The overall evaluation of KPS after chemotherapy was higher than before chemotherapy (P<0.01), and there was a significant difference. The toxicity was mainly myelosuppression, gastrointestinal reaction, alopecia, phlebitis, neurotoxicity was also seen, mostly mild, no paralytic ileus occurred. Conclusion Combination chemotherapy with carbamate-negative vinblastine is effective in the treatment of advanced breast cancer, but bone marrow toxicity is also heavier and should be used with caution.