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目的探讨尼莫地平联合复方丹参滴丸治疗脑供血不足的临床疗效。方法选取娄底市中心医院2015年2月—2017年2月收治的脑供血不足患者50例,随机将患者分为单一组与联合组,各25例。单一组患者予以尼莫地平治疗,联合组患者予以尼莫地平联合复方丹参滴丸治疗,两组患者连续治疗14 d。比较两组患者临床疗效、治疗前后血液流变学指标(血浆黏度、红细胞变形指数、红细胞聚集指数)及生活质量评分,观察两组患者不良反应发生情况。结果联合组患者治疗总有效率高于单一组(P<0.05)。治疗前两组患者血浆黏度、红细胞变形指数、红细胞聚集指数及生活质量评分比较,差异无统计学意义(P>0.05);治疗后联合组患者血浆黏度、红细胞变形指数、红细胞聚集指数低于单一组,生活质量评分高于单一组(P<0.05)。两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论尼莫地平联合复方丹参滴丸治疗脑供血不足的临床疗效确切,可有效改善患者血液流变学,提升生活质量,且不良反应少。
Objective To investigate the clinical efficacy of nimodipine combined with compound danshen dripping pills in treating cerebral insufficiency. Methods Fifty patients with cerebral insufficiency admitted from February 2015 to February 2017 in Loudi Central Hospital were randomly divided into single group and combined group, with 25 cases in each group. A single group of patients treated with nimodipine, combined group of patients treated with nimodipine combined with compound Danshen dripping pills, two groups of patients for 14 days of continuous treatment. The clinical curative effect, hemorheological indexes (plasma viscosity, erythrocyte deformability index, erythrocyte aggregation index) and quality of life before and after treatment were compared between two groups to observe the adverse reactions of the two groups. Results The total effective rate of treatment in combination group was higher than that in single group (P <0.05). There were no significant differences in plasma viscosity, erythrocyte deformability index, erythrocyte aggregation index and quality of life scores before treatment in the two groups (P> 0.05). After treatment, plasma viscosity, erythrocyte deformability index and erythrocyte aggregation index were lower in the combined group than in the single Group, quality of life scores were higher than single group (P <0.05). Two groups of patients with adverse reactions, the difference was not statistically significant (P> 0.05). Conclusion Nimodipine combined with compound Danshen dripping pills is effective in treating cerebral insufficiency. It can effectively improve the patients’ hemorrheology, improve the quality of life, and have fewer adverse reactions.