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采用Milunsky及Haddow介绍的指导原则,制定了母血清甲胎蛋白(MSAFP)筛查方案,并回顾研究了2年多经治的5 000余例MSAFP筛查结果。指导原则为:①制定实验室与妇产科提供的关键后勤供给间的具体合作方案;②实验室要具有通过内部质量控制方案的MSAFP检测条例;③确定15～25孕周正常MSAFP值的参考数据;④制定血清AFP值母体重矫正方案以及特殊病例(如胰岛素依赖型糖尿病)的标准;⑤确定进一步作血清或羊水试验的指征;⑥规定直接向孕妇经治医师通报异常结果以及预约孕妇会诊和遗传咨询的步骤;⑦参与外部质量控制方案。
Based on the guidelines introduced by Milunsky and Haddow, a screening program for maternal serum alpha-fetoprotein (MSAFP) was developed and more than 5,000 MSAFP screening studies reviewed over two years were reviewed. The guiding principles are as follows: (1) to establish the specific cooperation plan between the laboratory and the obstetrics and gynecology department to provide the key logistics supply; (2) to have the laboratory to pass the MSAFP testing regulations through the internal quality control program; (3) to determine the normal MSAFP value of 15 to 25 gestational weeks Data; ④ develop serum AFP values of maternal re-correction programs and special cases (such as insulin-dependent diabetes) standards; ⑤ determine further tests for serum or amniotic fluid indications; ⑥ provisions directly to the pregnant women informed of abnormal results and booking pregnant women Consultation and genetic counseling steps; ⑦ participate in external quality control programs.