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目的:研究探讨米索前列醇预防产后出血的疗效。方法:将足月正常产妇170例,随机分为缩宫素组和缩宫素+米索前列醇组(米索前列醇组)。缩宫素组,在胎儿娩出后单用缩宫素;米索前列醇组,在胎儿娩出后应用缩宫素的同时,立即舌下含化米索前列醇400μg。观察两组产时、产后出血量,血压及血红蛋白等。结果:产后2h内平均出血量,缩宫素组为239.25±113.11ml,米索前列醇组为189.17±125.49ml,差异非常显著(P<0.01);两组产后血红蛋白比较,差异非常显著(P<0.01)。两组用药前、后的血压变化无显著差异(P>0.05)。结论:米索前列醇与缩宫素联合应用能较好地预防产后出血。
Objective: To investigate the efficacy of misoprostol in preventing postpartum hemorrhage. Methods: 170 full-term normal mothers were randomly divided into oxytocin group and oxytocin + misoprostol group (misoprostol group). Oxytocin group, after the fetus was delivered with oxytocin alone; misoprostol group, oxytocin after the fetus was delivered at the same time, immediately sublingual misoprostol 400μg. Observe the two groups of labor, postpartum hemorrhage, blood pressure and hemoglobin. Results: The average amount of bleeding within 2h postpartum was 239.25 ± 113.11ml for oxytocin group and 189.17 ± 125.49ml for misoprostol group (P <0.01). The differences of postpartum hemoglobin between the two groups were significant (P <0.01). There was no significant difference in blood pressure between the two groups before and after treatment (P> 0.05). Conclusion: The combination of misoprostol and oxytocin can prevent postpartum hemorrhage.