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狼疮肾炎(LN)是指系统性红斑狼疮(SLE)合并双肾组织不同程度免疫性损害,同时具有明显肾功能损伤临床表现的一种自身免疫性疾病,是导致慢性肾功能衰竭的一个重要原因。典型的LN诊断并不困难,但早期、不典型或轻型LN,易漏诊或误诊。许多研究表明,CXC趋化因子配体10(CXCL10)在LN病理发展过程中起重要作用,可以作为一个敏感的生物标志物,提高LN诊断的敏感性。本文回顾CXCL10及其受体CXC趋化因子受体3(CXCR3)的结构和生物学功能,阐述其在LN中的作用,以期对LN临床诊断及病理发展的控制有所帮助。
Lupus nephritis (LN) is an autoimmune disease of systemic lupus erythematosus (SLE) combined with varying degrees of renal damage in both kidneys and clinical manifestations of significant renal impairment, and is an important cause of chronic renal failure . A typical LN diagnosis is not difficult, but early, atypical or mild LN is misdiagnosed or misdiagnosed. Many studies have shown that CXCL chemokine ligand 10 (CXCL10) plays an important role in the development of LN and can be used as a sensitive biomarker to improve the diagnostic sensitivity of LN. This review reviews the structure and biological functions of CXCL10 and its receptor CXCR3 and elucidates its role in LN in the hope of helping with the clinical diagnosis and pathological development of LN.