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目的探讨男性新生儿红细胞葡萄糖6磷酸脱氢酶(G6PD)活性中度缺乏的原因。方法根据遗传规律,把G6PD活性分为正常、中度缺乏和显著缺乏,并对我院2000年至2005年10月出生的10733名新生儿的资料与各地检测G6PD活性报道的资料进行比较、分析和研究。结果男性新生儿G6PD活性中度缺乏发生率约为1.5%～2.5%(约占男性新生儿G6PD活性总缺乏率的15%～25%)。结论本研究发现男性新生儿G6PD活性中度缺乏是客观存在的并和孟德尔遗传定律矛盾,它与G6PD变异型的酶活性表现、统计学方法、糖尿病和溶血等多种因素等有关。
Objective To investigate the reason of the moderate lack of G6PD activity in neonatal neonates. Methods According to the law of inheritance, the G6PD activity was divided into normal, moderate deficiency and significant deficiency. The data of 10733 newborns born in our hospital from 2000 to October 2005 were compared with the data of the reported G6PD activity. And research. Results The incidence of moderate neonatal G6PD activity was about 1.5% -2.5% (about 15% -25% of the total neonatal G6PD activity deficiency). Conclusions This study found that the moderate deficiency of G6PD activity in male neonates is objective and contradicts the Mendelian law of inheritance. It is related to the G6PD variant enzyme activity, statistical methods, diabetes and hemolysis.