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目的:观察普罗布考对小鼠柯萨奇B3病毒性心肌炎的治疗作用。方法:对60只Balb/c系小鼠随机,分为病毒性心肌炎组(A组),普罗布考低剂量干预组(B组),普罗布考高剂量干预组(C组),正常对照组(D组)4组,每组15只,观察各组小鼠的生存情况及测量各组小鼠不同感染时点的血清肌钙蛋白Ⅰ。结果:A组生存率为60%,B组生存率为80%,C组生存率为86.7%,D组生存率100%。血清肌钙蛋白随着小鼠生存率的提高而下降。结论:普罗布考对小鼠病毒性心肌炎有治疗作用。
Objective: To observe the therapeutic effect of probucol on mice with Coxsackievirus B3 viral myocarditis. Methods: Sixty Balb / c mice were randomly divided into three groups: viral myocarditis group (A group), probucol low dose intervention group (B group), probucol high dose intervention group (C group), normal control group (D group) 4 groups, 15 rats in each group. The survival of mice in each group was observed and the serum troponin I at different infection times was measured. Results: The survival rate of group A was 60%, the survival rate of group B was 80%, the survival rate of group C was 86.7%, and the survival rate of group D was 100%. Serum troponin decreased with the survival rate of mice. Conclusion: Probucol has a therapeutic effect on viral myocarditis in mice.