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目的 比较NP和NIP两方案对非小细胞肺癌 (NSCLC)的治疗效果。方法 治疗晚期非小细胞肺癌 6 8例 ,用NP(NVB +DDP)方案治疗和NIP(NVB +IFO +DDP)方案治疗。结果 NIP组和NP组有效率分别为 6 0 7% (17/ 2 8)和 47 5 % (19/ 4 0 ) ,两者差异无显著性 (P >0 0 5 ,χ2 =1 15 )。主要毒性反应是骨髓抑制 ,且以白细胞和血小板下降明显。NIP组Ⅲ、Ⅳ度白细胞毒性占 73 2 % ,NP组占 77 5 % ,两组差异无显著性 (P >0 0 5 ,χ2 =1 99)。结论 NP和NIP方案同为治疗非小细胞肺癌有效方案 ,毒性可以耐受。
Objective To compare the therapeutic effects of NP and NIP regimens on non-small cell lung cancer (NSCLC). Methods Sixty-eight patients with advanced non-small cell lung cancer were treated with NP (NVB + DDP) regimen and NIP (NVB + IFO + DDP) regimen. Results The effective rates of NIP and NP groups were 60.7% (17/28) and 47.5% (19/40), respectively. There was no significant difference between the two groups (P > 0 05, χ 2 = 15). The main toxic reaction was myelosuppression, and the leukocytes and platelets decreased significantly. In the NIP group, the toxicity of III and IV leukocytes accounted for 73. 2%, and the NP group accounted for 77.5%. There was no significant difference between the two groups (P > 0 05, χ 2 = 199). Conclusion Both NP and NIP regimens are effective regimens for the treatment of non-small cell lung cancer and the toxicity can be tolerated.