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目的:探讨凋亡抑制蛋白livin在膀胱移行细胞癌中的表达及其临床意义。方法:应用SP免疫组织化学方法检测55例膀胱移行细胞癌及10例正常膀胱黏膜组织石蜡切片中livin表达的情况,结合临床资料分析其在膀胱移行细胞癌组织和正常膀胱黏膜中的表达及其与膀胱移行细胞癌临床病理分期、组织学分级和患者复发转移情况的关系。结果:livin在膀胱移行细胞癌标本中的表达阳性率为76.4%(42/55),而正常对照组中无1例呈阳性表达(P<0.01);livin的表达与膀胱移行细胞癌的初发和复发显著相关(P<0.05),但与组织学分级、临床病理分期、转移与否、肿瘤数目无关。结论:livin蛋白在膀胱移行细胞癌组织中表达明显上调,并与膀胱移行细胞癌的复发密切相关,livin蛋白可能通过抑制细胞凋亡,对膀胱移行细胞癌的发生发展起着重要作用,可作为膀胱移行细胞癌早期诊断和评判术后高复发风险的一项重要指标。
Objective: To investigate the expression of livin in bladder transitional cell carcinoma and its clinical significance. Methods: SP immunohistochemistry was used to detect the expression of livin in paraffin sections of 55 cases of BTCC and 10 cases of normal bladder mucosa. The expression of livin in bladder transitional cell carcinoma and normal bladder mucosa was analyzed by clinical data And clinicopathological stage of bladder transitional cell carcinoma, histological grade and recurrence and metastasis of patients. Results: The positive expression rate of livin in bladder transitional cell carcinoma specimens was 76.4% (42/55), while no positive expression was found in normal control group (P <0.01). The expression of livin was correlated with the expression of livin in bladder transitional cell carcinoma Hair and recurrence were significantly correlated (P <0.05), but not with histological grade, clinical stage, metastasis or tumor number. CONCLUSION: The expression of livin protein is significantly up-regulated in bladder transitional cell carcinoma and closely related to the recurrence of transitional cell carcinoma of the bladder. The livin protein may play an important role in the development and progression of bladder transitional cell carcinoma by inhibiting apoptosis. Bladder transitional cell carcinoma early diagnosis and evaluation of postoperative high recurrence risk is an important indicator.