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目的探讨自体外周血干细胞对肝硬化患者的治疗作用。方法选择肝硬化失代偿期患者35例,在内科综合治疗的基础上予自体外周血干细胞治疗作为A组,常规治疗20例作为对照组(B组)。A组经肝动脉将细胞悬液移植入肝脏,分别在治疗后第8周观察肝脏功能、临床症状及不良反应情况。结果 A组在治疗后第8周血浆白蛋白、胆碱酯酶明显升高,血清谷丙转氨酶、总胆红素水平下降,凝血指标好转,与对照组比较有显著性差异;临床症状和体征示:腹胀减轻30例(85.7%),食欲改善32例(91.4%),体力好转29例(82.9%),有腹水、胸水25例,减轻23例(92.0%)。在全部35例患者中未发生严重并发症,近期无不良反应出现。结论自体外周血干细胞治疗失代偿期肝硬化安全有效且副作用小,可作为肝硬化患者的临床治疗方案。
Objective To investigate the therapeutic effect of autologous peripheral blood stem cells on patients with liver cirrhosis. Methods Thirty-five patients with decompensated cirrhosis were enrolled in this study. A group was treated with autologous peripheral blood stem cells on the basis of comprehensive medical treatment and 20 cases were treated routinely as control group (group B). Group A was transplanted into the liver via the hepatic artery and the liver function, clinical symptoms and adverse reactions were observed at the 8th week after treatment. Results At the 8th week after treatment, serum albumin and cholinesterase in group A were significantly increased, the levels of serum alanine aminotransferase and total bilirubin were decreased, and the coagulation parameters were improved. There were significant differences between the two groups in clinical symptoms and signs There were 30 cases (85.7%) with bloating relief, 32 cases (91.4%) with appetite improvement, 29 cases (82.9%) with physical improvement, 25 cases with ascites and pleural effusion and 23 cases (92.0%) with relieved appetite. No serious complications occurred in all 35 patients and no adverse reactions occurred in the near future. Conclusion Autologous peripheral blood stem cells for the treatment of decompensated cirrhosis is safe and effective and has few side effects. It can be used as a clinical treatment for patients with cirrhosis.