论文部分内容阅读
老年病人逐年增加,而对老年药效学的知识相应不足。作者在老年志愿者中观察妥布拉霉素药代动力学,以期取得安全性评价和更有效的剂量方案。16位高龄老人(65～97岁)志愿者分成两组:一组由65～79岁老人组成平均年龄71.3±5.0岁另一组由81～97岁老人组成,平均年龄为86.7±5.7岁。每位志愿者静脉滴注1mg/kg妥布拉霉素,以100ml生理盐水稀释,1h内滴完。血样用放射免疫法检测,同时测定血清肌酐、肌酐清除率和β_2-微球蛋白浓度的变化。检测结果,两组妥布拉霉素分布容积(Vd)分别为0.37±0.16和0.45±0.01L/kg总消除率(CL_T)分别为1.79±0.78和1.31±0.35ml/min·kg,无统计学差别。而半衰
Elderly patients increase year by year, and the corresponding lack of knowledge of the elderly pharmacodynamics. The authors observed the tobramycin pharmacokinetics in elderly volunteers with a view to obtaining a safety assessment and a more effective dosage regimen. The 16-year-old (aged 65-97) volunteers were divided into two groups: one group consisting of 65-79-year-olds with an average age of 71.3 ± 5.0 years and the other group of 81-97-year-olds with an average age of 86.7 ± 5.7 years. Each volunteer intravenous infusion of 1mg / kg tobramycin, diluted with 100ml saline, drop within 1h. Blood samples were detected by radioimmunoassay, meanwhile serum creatinine, creatinine clearance and β_2-microglobulin concentration were measured. The results showed that the distribution volume (Vd) of two tobramycin groups was 0.37 ± 0.16 and 0.45 ± 0.01L / kg, respectively (1.79 ± 0.78 and 1.31 ± 0.35ml / min · kg, respectively) Learn difference. Half-bad