论文部分内容阅读
目的应用血氧饱和度对比成像(blood oxygenation level dependent,BOLD)的功能性磁共振技术结合0℃冰水刺激对人类大脑前庭皮质的定位进行研究,并探讨该方法在前庭皮质定位研究上的应用价值。方法在完全黑暗的环境下,对20例成年健康志愿者的右侧外耳道用0℃冰水15ml 持续15s 灌注后,然后采用1.5T Signa Infinity Twin+Excite 成像系统,采集脑部的 BOLD-fMRI的数据,最后通过 spm99软件对数据进行统计学分析(组分析)得到脑功能活动的图像。结果 17例受试者的扫描结果参与了最终的组分析。通过组分析后显示双侧的大脑皮质出现多个 BOLD 信号增强区,左侧为主,分别为后脑岛及部分颞顶连接皮质、颞上回、顶下小叶的缘上回及顶叶内侧面的楔前叶、枕叶的腹外侧区、舌回和楔叶、补充运动区、扣带回皮质。结论0℃冰水刺激结合功能性磁共振成像技术进一步证实了人类大脑存在一个广泛的皮质反应网络参与前庭信号的处理,而且该方法能对大脑的前庭皮质功能区进行精确定位,是一种敏感性高、重复性好的研究方法。
Objective To study the localization of human cerebral vestibular cortex by using functional magnetic resonance imaging of blood oxygenation level dependent (BOLD) combined with ice-water stimulation at 0 ℃, and to explore the application of this method in the localization of vestibular cortex value. Methods Twenty adult healthy volunteers were treated with 15ml perfusion of 15ml of ice water at 0 ℃ for 15s in a completely dark environment. The brains were collected with 1.5T Signa Infinity Twin + Excite imaging system for BOLD-fMRI Data, and finally by spm99 software for statistical analysis of the data (group analysis) to get brain function of the image. Results The results of the scan of 17 subjects were involved in the final group analysis. After group analysis, multiple BOLD signal enhancement regions appeared on both sides of the cerebral cortex, the left main, respectively, the posterior insular island and part of the temporal cortex connected to the cortex, the superior temporal gyrus, the superior and inferior parietal lobes and the medial parietal lobe Of the wedge anterior lobe, occipital lobe of the ventrolateral region, lingual gyrus and wedge leaves, add exercise area, cingulate cortex. Conclusions 0 ° C ice water stimulation combined with functional magnetic resonance imaging further confirmed the presence of a wide range of cortical response networks in the human brain involved in the processing of vestibular signals and that this method is sensitive to the precise localization of the cerebrum vestibular cortical functional areas High sex, reproducible research methods.