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在肿瘤侵袭转移过程中,肿瘤细胞首先脱离原位,与基底膜和细胞外基质中的大分子蛋白成分黏附,并激活与基质蛋白溶解相关的蛋白水解酶类如基质金属蛋白酶(MMPs),降解基底膜和细胞外基质,从而细胞移动并穿过基底膜和血管壁进入血液循环。在肿瘤细胞与细胞外基质的黏附过程中,整合蛋白起了非常重要的作用。Liu等根据整合蛋白β亚基和部分α亚基的保守序列设计的抗黏附β肽能阻断肿瘤细胞与基质的相互作用,对高转移的人肝癌裸鼠模型LCID20肝癌切除术后肝内转移和肺转移也具有强大抑制作用。在此基础上,本研究观察三聚β肽(β3)的抗肿瘤细胞迁移和侵袭的活性及对肿瘤细胞MMPs的影响。
During tumor invasion and metastasis, the tumor cells first detach from the in situ and adhere to macromolecular protein components in the basement membrane and the extracellular matrix and activate proteolytic enzymes such as matrix metalloproteinases (MMPs) that are associated with matrix protein lysis, degradation Basement membrane and extracellular matrix, so that cells move through the basement membrane and the vessel wall into the bloodstream. Integrin plays a very important role in the adhesion of tumor cells to the extracellular matrix. Liu et al. The anti-adhesion beta peptide designed according to the conserved sequence of integrin beta subunit and partial alpha subunit can block the interaction of tumor cells and matrix, and the intrahepatic metastasis of highly metastatic human hepatocellular carcinoma nude mouse model LCID20 after hepatectomy And lung metastasis also has a strong inhibitory effect. On this basis, we observed the anti-tumor cell migration and invasion activity of trimeric beta peptide (β3) and its effect on MMPs in tumor cells.