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目的探讨表皮生长因子受体(epidermal growth factor receptor,EGFR)在胰胆管汇合异常(pancreaticobiliary maljunction,PBM)及胆囊癌病人胆囊黏膜上皮中表达情况及其临床意义。方法应用免疫组化S-P法检测非PBM慢性胆囊炎组、PBM组和胆囊癌组病人胆囊黏膜上皮中EGFR蛋白的表达。结果各组胆囊黏膜上皮中EGFR表达:慢性胆囊炎组30例表达情况为(-)10例,(+)8例、(++)9例、(+++)3例;PBM组24例表达情况为(-)2例、(+)3例、(++)10例、(+++)9例;胆囊癌组28例表达情况为(-)1例、(+)6例、(++)10例、(+++)11例。结论 EGFR在PBM病人和胆囊癌病人胆囊黏膜上皮中均表达升高,EGFR对PMB病人胆囊黏膜上皮过度增生-肠化生-癌变过程有促进作用。
Objective To investigate the expression of epidermal growth factor receptor (EGFR) in the gallbladder mucosal epithelium of patients with pancreaticobiliary maljunction (PBM) and gallbladder carcinoma and its clinical significance. Methods The expression of EGFR protein in gallbladder mucosal epithelium of patients with chronic cholecystitis, PBM and gallbladder carcinoma was detected by immunohistochemical S-P method. Results The expression of EGFR in gallbladder mucosa epithelium of each group was 10 cases (+), 8 cases (+), (++) 9 cases, (+++) 3 cases; PBM group 24 cases (+) In 3 cases, (++) in 10 cases and (+++) in 9 cases. The expression of 28 cases in gallbladder carcinoma group was (-) in 1 case, (+ (++) 10 cases, (+++) 11 cases. Conclusion The expression of EGFR in gallbladder mucosa epithelium of patients with PBM and gallbladder carcinoma both increased, and EGFR could promote the process of gallbladder mucosa hyperplasia - intestinal metaplasia - carcinogenesis in patients with PMB.