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目的观察健脾化瘀方对肝细胞癌患者术后早期生活质量的影响。方法选择肝切除术后2周内的肝细胞癌患者60例,随机分为对照组和健脾化瘀方组,每组30例。两组患者均根据病情予常规西药对症治疗。健脾化瘀方组在常规西药对症治疗的基础上予以健脾化瘀方辨证加减治疗,每日1剂,连续每14天。在治疗前和治疗后分别用生活质量调查表(QLQ-C30)评估所有病人的生活质量。结果治疗后两组肝癌术后患者的躯体功能、角色功能、认知功能、情绪功能、社会功能、总体健康状况、疲劳、恶心呕吐、疼痛、睡眠障碍、食欲下降等维度的评分和治疗前比较有明显的改善(P<0.01),且健脾化瘀方组的改善程度显著优于对照组(P<0.05~0.01)。而且健脾化瘀方组的便秘、腹泻的评分较治疗前明显改善(P<0.05)。结论健脾化瘀方可明显改善肝癌术后患者早期的生活质量,值得临床推广应用。
Objective To observe the effect of Jianpi Huayu Recipe on early postoperative quality of life of patients with hepatocellular carcinoma. Methods Sixty patients with hepatocellular carcinoma within 2 weeks after hepatectomy were randomly divided into control group and Jianpi Huayu Recipe group, 30 cases in each group. Two groups of patients according to the disease to conventional Western symptomatic treatment. Jianpi Huayu prescription group on the basis of conventional western medicine symptomatic treatment to Jianpi Huayu Fang syndrome differentiation plus treatment, a day, for every 14 days. Quality of life was assessed in all patients with QLQ-C30 before and after treatment. Results After treatment, the scores of body function, role function, cognitive function, emotional function, social function, general health status, fatigue, nausea and vomiting, pain, sleep disturbance and loss of appetite were compared between the two groups before and after treatment (P <0.01). The improvement of Jianpi Huayu Recipe group was significantly better than that of the control group (P <0.05 ~ 0.01). Moreover, the scores of constipation and diarrhea in Jianpi Huayu prescription group were significantly improved than before treatment (P <0.05). Conclusion Jianpi Huayu Recipe can significantly improve the early postoperative quality of life of patients with liver cancer, worthy of clinical application.