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目的:了解老年糖耐量减低患者不同血糖水平与高敏C反应蛋白之间的相关性。方法:308例老年非糖尿病患者,根据口服葡萄糖耐量试验结果分为糖耐量正常组80例及糖耐量减低组(研究组)228例,再根据餐后2 h血糖水平将研究组分为低高血糖组85例,中高血糖组72例及高高血糖组71例。测定各组身高、体质量、血压、血脂、血清C反应蛋白、空腹胰岛素等生化指标并比较分析。结果:低密度脂蛋白对照组低于糖耐量减低各组,而高密度脂蛋白对照组高于糖耐量减低各组,对照组与糖耐量减低各组比较差异均有统计学意义(P<0.05),但糖耐量减低3组间无论血糖水平高低差异均无统计学意义(P>0.05);高高血糖组高敏C反应蛋白及胰岛素抵抗指数水平最高,分别为(1.69±0.93)mg/dL,(2.60±2.06)mg/dL,与其他各组比较差异均有统计学意义(P<0.01),而对照组、低高血糖组、中高血糖组组间比较差异无统计学意义(P>0.05)。相关分析显示高敏C反应蛋白与餐后2 h血糖呈正相关。结论:糖耐量减低患者已存在脂代谢异常,餐后2 h血糖为10.0～11.1 mmol/L的老年糖耐量减低患者是动脉粥样硬化的高危人群,需早期进行生活方式干预和药物治疗。
Objective: To understand the correlation between different blood glucose levels and high-sensitivity C-reactive protein in elderly patients with impaired glucose tolerance. Methods: According to the results of oral glucose tolerance test, 308 elderly patients with non-diabetic were divided into two groups according to oral glucose tolerance test: 80 cases with normal glucose tolerance group and 228 cases with impaired glucose tolerance group (study group). According to the blood glucose level at 2 hours after meal, 85 cases of blood glucose, 72 cases of hyperglycemia and hyperglycemia in 71 cases. The biochemical indexes such as height, body weight, blood pressure, blood lipid, serum C-reactive protein and fasting insulin in each group were determined and compared. Results: The low-density lipoprotein control group was lower than the glucose tolerance group, but the high density lipoprotein control group was higher than the impaired glucose tolerance group, the difference between the control group and the impaired glucose tolerance group was statistically significant (P <0.05 ), But there was no significant difference in glucose tolerance between the three groups (P> 0.05). The levels of high sensitivity C-reactive protein and insulin resistance were the highest in hyperglycemia group (1.69 ± 0.93) mg / dL , (2.60 ± 2.06) mg / dL, respectively, which were significantly different from other groups (P <0.01), but there was no significant difference between the control group, low hyperglycemia group and middle hyperglycemia group (P> 0.05). Correlation analysis showed that high-sensitivity C-reactive protein and 2 h postprandial blood glucose was positively correlated. CONCLUSION: Patients with impaired glucose tolerance have abnormal lipid metabolism. Elderly patients with impaired glucose tolerance at a glucose level of 10.0-11.1 mmol / L at 2 h postprandial are high risk groups of atherosclerosis. Lifestyle intervention and medication are required early.