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目的:观察氨氯地平片治疗非杓型老年高血压患者对血压昼夜节律异常及对动态动脉硬化指数(AASI)的影响。方法:80例患者每日晨8时顿服氨氯地平5~10 mg/d,服药前及治疗8周后行24 h动态血压监测。结果:80例完成治疗的患者中,60例血压昼夜节律异常逆转,同时改善AASI。而20例血压昼夜节律无逆转,AASI与治疗前比较无差异。结论:经氨氯地平片治疗后,75%的非杓型高血压患者,可改善血压昼夜节律异常及AASI。
Objective: To observe the effect of amlodipine on the abnormal circadian rhythm of blood pressure and the dynamic arteriosclerosis index (AASI) in non-dipper elderly hypertensive patients. Methods: Eighty patients were treated with amlodipine 5 ~ 10 mg daily at 8:00 a.m., and ambulatory blood pressure monitoring was performed 24 hours before treatment and 8 weeks after treatment. Results: Out of the 80 patients who completed the treatment, abnormal blood pressure circadian rhythms were reversed in 60 patients and AASI was also improved. 20 cases of blood pressure circadian rhythm no reversal, AASI and no difference before treatment. Conclusion: After treatment with amlodipine, 75% of non-dipper hypertensive patients can improve abnormal circadian rhythm of blood pressure and AASI.