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目的评价乳腺癌患者血清肿瘤坏死因子-α(TNF-α)和白细胞介素-6(IL-6)水平及临床意义。方法 80例乳腺癌患者作为研究组,同期80例体检健康者作为对照组。对两组血清TNF-α和IL-6水平进行比较,并比较乳腺癌未手术骨转移者与术后复发者的血清TNF-α和IL-6水平。结果研究组血清TNF-α(98.54±59.90)ng/L、IL-6(53.34±35.85)ng/L水平均高于对照组的(21.26±8.70)、(29.62±11.73)ng/L,差异均具有统计学意义(P<0.05)。乳腺癌未手术骨转移者的血清TNF-α为(186.16±53.76)ng/L、IL-6为(78.44±40.04)ng/L水平均高于术后复发者的(76.57±44.25)、(50.26±34.23)ng/L,差异均具有统计学意义(P<0.05)。结论乳腺癌的发生、发展与患者血清中的TNF-α和IL-6水平密切相关,临床可依据其测定结果进行病情观察和评定治疗效果,并为预后评估提供参考信息。
Objective To evaluate the serum levels of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in patients with breast cancer and their clinical significance. Methods 80 cases of breast cancer patients as a research group, the same period 80 cases of physical examination as a control group. The levels of TNF-α and IL-6 in serum of the two groups were compared, and the levels of serum TNF-α and IL-6 in breast cancer patients without surgical bone metastasis and postoperative recurrence were compared. Results The levels of serum TNF-α (98.54 ± 59.90) ng / L and IL-6 (53.34 ± 35.85) ng / L in the study group were significantly higher than those in the control group (21.26 ± 8.70) and (29.62 ± 11.73) ng / All were statistically significant (P <0.05). The serum level of TNF-α in the patients with breast cancer without metastasis was (186.16 ± 53.76) ng / L and IL-6 was (78.44 ± 40.04) ng / L, respectively, higher than that in patients with recurrence (76.57 ± 44.25) 50.26 ± 34.23) ng / L, the differences were statistically significant (P <0.05). Conclusions The occurrence and development of breast cancer are closely related to the levels of TNF-α and IL-6 in the serum of patients. The clinical manifestations can be observed according to the results and the therapeutic effect can be assessed. And it can provide reference information for the prognosis evaluation.