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既往对同一动物同时研究庆大霉毒耳毒性与肾毒性的报导很少。原文作者用19只重330～400g、耳郭声反射正常、无呼吸道感染的豚鼠作了这方面的研究。其中试验组15只,皮下注射庆大霉素60mg/kg/日,每日1次,连续3周。对照组4只。在治疗前、后和治疗期间多次定期检查庆大霉素血浓度、血清肌酐和尿素氮、溶酶体酶(N-乙酰-β-D 葡萄糖胺酶,NAG)和刷状缘酶(γ-谷氨酸转肽酶,GPT);听功能用短声刺激听皮层诱发电位检查;在暗室内用眼周电极描记对阻尼正弦振荡的眼震反应以检查前庭功能。结果发现,庆大霉素耳及肾毒
Previous reports on the same animal at the same time of studying the toxicity and nephrotoxicity of Candida were not reported. The original author with 19 weighing 330 ~ 400g, Auricular reflex normal, no respiratory tract infection in guinea pigs made this research. One experimental group 15, subcutaneous gentamicin 60mg / kg / day, once daily for 3 weeks. Control group 4. The concentrations of gentamycin, serum creatinine and urea nitrogen, lysosomal enzymes (N-acetyl-β-D glucosaminidase, NAG) and brush border enzyme (γ - Glutamic acid transpeptidase, GPT); auditory function with short-tone stimuli auditory cortex evoked potentials; ocular findings in the dark room on the damping sinusoidal oscillation of the nystagmus to check the vestibular function. The results showed that gentamicin ear and kidney toxicity