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交感神经系统活动与高血压的关系尚未明了,正常人与高血压病患者周围循环中儿茶酚胺水平的差别很小,或则结果并不一致。但高血压病患者常有异常的交感神经系统反应,即通过肾上腺素能受体(受体)引致的血管收缩作用较之正常人增强,由此推想这些受体不正常。近年来由于对这些特异性受体的分类和肾上腺素能的神经传递有了新的认识,维持交感神经系统活动的平衡和稳定成为治疗高血压病的基础。多年来应用β受体拮抗药疗效不甚满意,自从1976年哌唑嗪(prazosine)应用于临
The relationship between sympathetic nervous system activity and hypertension is unclear, and there is little difference in circulating catecholamines between normal and hypertensive patients, or the results are not consistent. However, patients with hypertension often have abnormal sympathetic nervous system responses, that is, vasoconstriction induced by adrenergic receptors (receptors) is enhanced compared with that of normal subjects, and thus, it is assumed that these receptors are abnormal. In recent years, due to the classification of these specific receptors and adrenergic neurotransmission has gained new understanding, maintaining the balance and stability of sympathetic nervous system activity as the basis for the treatment of hypertension. Over the years the application of β-receptor antagonist efficacy is not satisfactory, since 1976 prazosine (prazosine)